High- Intensity (lowers LDL-C ≥ 50%) 63. E11-E18 7 July, 2009 2) Degreef LE and Opdam FL. CMAJ 181 (1-2). Association between statin-associated myopathy and skeletal muscle damage. Whether use of high‐intensity statins is more important than achieving low‐density lipoprotein cholesterol (LDL ‐C) target remains controversial in patients with coronary artery disease.We sought to investigate the association between statin intensity and long‐term clinical outcomes in patients achieving treatment target for LDL ‐C after percutaneous coronary intervention. 1) Markus Mohaupt and others. Low and medium intensity statins by all CCGs. The tolerability and efficacy of low-dose simvastatin in statin-intolerant patients. 52. Moderate- or low-intensity statin was effective enough in reaching National Cholesterol Education Program Adult Treatment Panel III LDL-C target goals in Koreans. 61. HMG-CoA Reductase Inhibitor. a 31% to 40% reduction is medium intensity. Simvastatin. Fluvastatin. Statin Intensity %LDL-C. For the purpose of this guideline, statins are grouped into 3 different intensity categories according to the percentage reduction in low density lipoprotein cholesterol: a 20% to 30% reduction is low intensity. 56. Atorvastatin. one that reduces LDL cholesterol by 40% or more) with a low acquisition cost. Reduction. Remarkably, statin use was associated with improved outcomes at all levels of low-density lipoprotein, even in subjects with values below 40 mg/dL. 60. Pitavastatin. a reduction of more than 40% is high intensity. 80mg ($9 gen, $236 br) 59. Pravastatin. Low-intensity statin showed around 30% LDL-C reduction from the baseline level in Koreans, which is comparable to moderate-intensity stat … Rosuvastatin. Background. 20 mg ($196) 54. Eur J Intern Med 21(4):293-6 Nov 2010 3) Matalka MS, Ravnan MC, Deedwania PC. Statin Moderate Daily Adult Dose Providing Similar Average LDL-Lowering(based on reference 1 unless otherwise denoted) Low -intensity (expected LDL reduction <30%) -intensity (expected LDL reduction 30 to <50%) High intensity (expected LDL reduction 50% or higher) Pitavastatin (Livalo)(U.S.) 1 mg 2 to 4 mg Use an initial dose of 1 mg in patients 10 mg ($196) 50. 58. Lovastatin. Although these findings were retrospective in nature and confirmatory studies are required, this report suggests that statins can safely be used in patients with extremely low low-density lipoprotein levels and may lead to improved survival. 40 mg ($196) 62. Why it matters: 2014 NICE guidance on primary and secondary lipid modification recommends the use of a high-intensity statin (i.e.


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